American Airlines said it will launch four new routes from its Los Angeles hub later this fall.
The carrier will begin daily flights to Edmonton, Vancouver and San Antonio on October 2 and add Tampa service on November 6.
"Providing service from Los Angeles to these destinations strengthens our LAX hub which plays a vital role in our domestic and international network strategy," said American vice president of network and schedule planning Chuck Schubert in a statement.
The Canadian service and flights to San Antonio will be operated by US Airways Express with a Bombardier CRJ-900 aircraft. American Airlines' mainline operations will fly the Tampa route with a Boeing 737-800 aircraft.
American will also drop its service to Hartford, Conn. from Los Angeles. The airline said it will serve 53 domestic and international destinations from Los Angeles with the schedule changes this fall.